Table 2. Role of K_2P channels in different pathological conditions The table summarizes all the findings on K_2P channels relevant to human diseases, including altered channel expression, channel mutation, and genetic variants associated with different pathological conditions. The channel name is based on the IUPHAR nomenclature. TNBC: triple-negative breast cancer, ALL: acute lymphoblastic leukemia, HCC: hepatocellular carcinoma, MS: multiple sclerosis, SNP: single nucleotide polymorphism, SCD: sickle cell disease, PAH: pulmonary artery hypertension, IVF: idiopathic ventricular fibrillation, LQTS: long QT syndrome, FHEIG: facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome, BBMRS: Birk Barel mental retardation syndrome, SSRIs: selective serotonin reuptake inhibitors, MDD: major depressive disorder, IGE: Idiopathic generalized epilepsies, T2D: type 2 diabetes, MODY: maturity-onset diabetes of the young, BEN: Balkan endemic nephropathy, DO: detrusor overactivity, LUTS: lower urinary tract symptoms, HSCR: Hirschsprung disease. CNS: central nervous system, GI: gastrointestinal system